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Medical History

BEING MORTAL

BEING MORTAL

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Named a Best Book of the Year by The Washington Post, The New York Times Book Review, NPR, and Chicago Tribune, now in paperback with a new reading group guide

Medicine has triumphed in modern times, transforming the dangers of childbirth, injury, and disease from harrowing to manageable. But when it comes to the inescapable realities of aging and death, what medicine can do often runs counter to what it should.

Through eye-opening research and gripping stories of his own patients and family, Gawande reveals the suffering this dynamic has produced. Nursing homes, devoted above all to safety, battle with residents over the food they are allowed to eat and the choices they are allowed to make. Doctors, uncomfortable discussing patients' anxieties about death, fall back on false hopes and treatments that are actually shortening lives instead of improving them.

In his bestselling books, Atul Gawande, a practicing surgeon, has fearlessly revealed the struggles of his profession. Now he examines its ultimate limitations and failures-in his own practices as well as others'-as life draws to a close. Riveting, honest, and humane, Being Mortal shows how the ultimate goal is not a good death but a good life-all the way to the very end.

BIOGRAPHY OF RESISTANCE: THE E

BIOGRAPHY OF RESISTANCE: THE E

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Award-winning Boston University educator and researcher Muhammad H. Zaman provides a chilling look at the rise of antibiotic-resistant superbugs, explaining how we got here and what we must do to address this growing global health crisis.

In September 2016, a woman in Nevada became the first known case in the U.S. of a person who died of an infection resistant to every antibiotic available. Her death is the worst nightmare of infectious disease doctors and public health professionals. While bacteria live within us and are essential for our health, some strains can kill us. As bacteria continue to mutate, becoming increasingly resistant to known antibiotics, we are likely to face a public health crisis of unimaginable proportions. "It will be like the great plague of the middle ages, the influenza pandemic of 1918, the AIDS crisis of the 1990s, and the Ebola epidemic of 2014 all combined into a single threat," Muhammad H. Zaman warns.

The Biography of Resistance is Zaman's riveting and timely look at why and how microbes are becoming superbugs. It is a story of science and evolution that looks to history, culture, attitudes and our own individual choices and collective human behavior. Following the trail of resistant bacteria from previously uncontacted tribes in the Amazon to the isolated islands in the Arctic, from the urban slums of Karachi to the wilderness of the Australian outback, Zaman examines the myriad factors contributing to this unfolding health crisis--including war, greed, natural disasters, and germophobia--to the culprits driving it: pharmaceutical companies, farmers, industrialists, doctors, governments, and ordinary people, all whose choices are pushing us closer to catastrophe.

Joining the ranks of acclaimed works like Microbe Hunters, The Emperor of All Maladies, and Spillover, A Biography of Resistance is a riveting and chilling tale from a natural storyteller on the front lines, and a clarion call to address the biggest public health threat of our time.

BITTEN

BITTEN

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A riveting thriller reminiscent of The Hot Zone, this true story dives into the mystery surrounding one of the most controversial and misdiagnosed conditions of our time--Lyme disease--and of Willy Burgdorfer, the man who discovered the microbe behind it, revealing his secret role in developing bug-borne biological weapons, and raising terrifying questions about the genesis of the epidemic of tick-borne diseases affecting millions of Americans today.

While on vacation on Martha's Vineyard, Kris Newby was bitten by an unseen tick. That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year.

As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong.

In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease.

A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it.

--Kirkus Reviews (starred review)
BITTEN: THE SECRET HISTORY OF

BITTEN: THE SECRET HISTORY OF

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A riveting thriller reminiscent of The Hot Zone, this true story dives into the mystery surrounding one of the most controversial and misdiagnosed conditions of our time--Lyme disease--and of Willy Burgdorfer, the man who discovered the microbe behind it, revealing his secret role in developing bug-borne biological weapons, and raising terrifying questions about the genesis of the epidemic of tick-borne diseases affecting millions of Americans today.

While on vacation on Martha's Vineyard, Kris Newby was bitten by an unseen tick. That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year.

As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong.

In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease.

A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it.

BOTTLE OF LIES

BOTTLE OF LIES

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A NEW YORK TIMES BESTSELLER

New York Times 100 Notable Books of 2019

New York Public Library Best Books of 2019

Kirkus Reviews Best Health and Science Books of 2019

Science Friday Best Books of 2019

New postscript by the author

From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale--The Jungle for pharmaceuticals

Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?

Katherine Eban's Bottle of Lies exposes the deceit behind generic-drug manufacturing--and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.

The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?

A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world's greatest public-health innovation has become one of its most astonishing swindles.

--New York Times
BRAIN ON FIRE

BRAIN ON FIRE

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An award-winning memoir and instant New York Times bestseller--and inspiration for the major motion picture starring Chloë Grace Moretz--that goes far beyond its riveting medical mystery, Brain on Fire is the powerful account of one woman's struggle to recapture her identity.

When twenty-four-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she'd gotten there. Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?

In a swift and breathtaking narrative, Susannah tells the astonishing true story of her descent into madness, her family's inspiring faith in her, and the lifesaving diagnosis that nearly didn't happen. "A fascinating look at the disease that...could have cost this vibrant, vital young woman her life" (People), Brain on Fire is an unforgettable exploration of memory and identity, faith and love, and a profoundly compelling tale of survival and perseverance that is destined to become a classic.

BUTCHERING ART

BUTCHERING ART

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Winner, 2018 PEN/E.O. Wilson Prize for Literary Science Writing
Short-listed for the 2018 Wellcome Book Prize
A Top 10 Science Book of Fall 2017, Publishers Weekly
A Best History Book of 2017, The Guardian

Warning: She spares no detail! --Erik Larson, bestselling author of Dead Wake

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of nineteenth-century surgery and shows how it was transformed by advances made in germ theory and antiseptics between 1860 and 1875. She conjures up early operating theaters--no place for the squeamish--and surgeons, who, working before anesthesia, were lauded for their speed and brute strength. These pioneers knew that the aftermath of surgery was often more dangerous than patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the riddle and change the course of history.

Fitzharris dramatically reconstructs Lister's career path to his audacious claim that germs were the source of all infection and could be countered by a sterilizing agent applied to wounds. She introduces us to Lister's contemporaries--some of them brilliant, some outright criminal--and leads us through the grimy schools and squalid hospitals where they learned their art, the dead houses where they studied, and the cemeteries they ransacked for cadavers.

Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

DEMON IN THE FREEZER

DEMON IN THE FREEZER

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"The bard of biological weapons captures the drama of the front lines."--Richard Danzig, former secretary of the navy

The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with "hot" agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.

Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world's most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.

Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government's response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.

Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.

ELDERHOOD

ELDERHOOD

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Finalist for the Pulitzer Prize in General Nonfiction
A New York Times Bestseller
Longlisted for the Andrew Carnegie Medal for Excellence in Nonfiction
Winner of the WSU AOS Bonner Book Award

As revelatory as Atul Gawande's Being Mortal, physician and award-winning author Louise Aronson's Elderhood is an essential, empathetic look at a vital but often disparaged stage of life.

For more than 5,000 years, old has been defined as beginning between the ages of 60 and 70. That means most people alive today will spend more years in elderhood than in childhood, and many will be elders for 40 years or more. Yet at the very moment that humans are living longer than ever before, we've made old age into a disease, a condition to be dreaded, denigrated, neglected, and denied.

Reminiscent of Oliver Sacks, noted Harvard-trained geriatrician Louise Aronson uses stories from her quarter century of caring for patients, and draws from history, science, literature, popular culture, and her own life to weave a vision of old age that's neither nightmare nor utopian fantasy--a vision full of joy, wonder, frustration, outrage, and hope about aging, medicine, and humanity itself.

Elderhood is for anyone who is, in the author's own words, an aging, i.e., still-breathing human being.

EMPEROR OF ALL MALADIES

EMPEROR OF ALL MALADIES

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Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is a magnificent, profoundly humane "biography" of cancer--from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence.

Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist.

From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive--and to increase our understanding of this iconic disease.

Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

GENE: AN INTIMATE HISTORY

GENE: AN INTIMATE HISTORY

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The #1 NEW YORK TIMES Bestseller
The basis for the PBS Ken Burns Documentary The Gene: An Intimate History

From the Pulitzer Prize-winning author of The Emperor of All Maladies--a fascinating history of the g

GRAY'S ANATOMY

GRAY'S ANATOMY

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The famous, unconditionally guaranteed, durable paperback edition with high-quality paper and binding.
GUT REV/E

GUT REV/E

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"Everything you ever wanted to know about the gut (and then some)."--SELF

In this New York Times bestseller, scientist Giulia Enders reveals the secrets of your digestive system--including new research on the connection between your gut and your brain.

For too long, the gut has been the body's most ignored and least appreciated organ. But it does more than just dirty work; it's at the core of who we are.

With quirky charm, science star and medical doctor Giulia Enders explains the gut's magic, answering questions like: Why does acid reflux happen? What's really up with gluten and lactose intolerance? How does the gut affect obesity and mood? In this revised edition of her beloved bestseller, Enders includes a new section on the brain-gut connection, and dives into ground-breaking discoveries of psychobiotics--microbes with psychological effects that can influence mental health conditions like depression and even stress.

At long last, this beguiling book will make you finally listen to those butterflies in your stomach: they're trying to tell you something important.

HIDDEN VALLEY ROAD: INSIDE THE

HIDDEN VALLEY ROAD: INSIDE THE

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The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease.

Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?
What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.
With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

LIFESPAN: WHY WE AGE--AND WHY

LIFESPAN: WHY WE AGE--AND WHY

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A NEW YORK TIMES BESTSELLER

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time's most influential people.

It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: "Aging is a disease, and that disease is treatable."

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab at Harvard--that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat--that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

MEDICAL BONDAGE: RACE, GENDER,

MEDICAL BONDAGE: RACE, GENDER,

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The accomplishments of pioneering doctors such as John Peter Mettauer, James Marion Sims, and Nathan Bozeman are well documented. It is also no secret that these nineteenth-century gynecologists performed experimental caesarean sections, ovariotomies, and obstetric fistula repairs primarily on poor and powerless women. Medical Bondage breaks new ground by exploring how and why physicians denied these women their full humanity yet valued them as "medical superbodies" highly suited for medical experimentation.

In Medical Bondage, Cooper Owens examines a wide range of scientific literature and less formal communications in which gynecologists created and disseminated medical fictions about their patients, such as their belief that black enslaved women could withstand pain better than white "ladies." Even as they were advancing medicine, these doctors were legitimizing, for decades to come, groundless theories related to whiteness and blackness, men and women, and the inferiority of other races or nationalities.

Medical Bondage moves between southern plantations and northern urban centers to reveal how nineteenth-century American ideas about race, health, and status influenced doctor-patient relationships in sites of healing like slave cabins, medical colleges, and hospitals. It also retells the story of black enslaved women and of Irish immigrant women from the perspective of these exploited groups and thus restores for us a picture of their lives.

MEMOIRS OF A WOMAN DOCTOR

MEMOIRS OF A WOMAN DOCTOR

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Rebelling against the contraints of family and society, a young Egyptian woman decides to study medicine, becoming the only woman in a class of men. Her encounters with the other students mdash; as well as the male and female corpses in the autopsy room--intensify her dissatisfaction with and search for identity. She realizes men are not gods as her mother had taught her, that science cannot explain everything, and that she cannot be satisfied by living a life purely of the mind.

After a brief and unhappy marriage, she throws herself into her work, becoming a successful physician, but at the same time, she becomes aware of injustice and hypocrisy in society. Fulfillment and love come to her at last in a wholly unexpected way.

". . . Memoirs of a Woman Doctor by Nawal el Saadawi, one of the leading Egyptian feminist writers, reveals the contradictions embedded in women's self-oppressive struggle against patriarchy."--Khadidiatau Gueye, Research in African Literatures (Indiana University Press)

Nawal el Saadawi, born in 1931 in Kafr Tahla, Egypt, is an Egyptian physician, psychiatrist, author and activist. She is the founder and president of the Arab Women's Solidarity Association and co-founder of the Arab Association for Human Rights. In 2004 she won the North-South Prize from the Council of Europe. In 2005 she won the inana International Prize in Belgium. In 2010 she won the Sean MacBride Peace Prize from the International Peace Bureau. She has written and published other novels, memoirs, plays, non-fiction and short stories including Woman at Point Zero, The Hidden Face of Eve and The Fall of the Imam.

NATURAL CAUSES

NATURAL CAUSES

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From the celebrated author of Nickel and Dimed, Barbara Ehrenreich explores how we are killing ourselves to live longer, not better.

A razor-sharp polemic which offers an entirely new understanding of our bodies, ourselves, and our place in the universe, Natural Causes describes how we over-prepare and worry way too much about what is inevitable. One by one, Ehrenreich topples the shibboleths that guide our attempts to live a long, healthy life -- from the importance of preventive medical screenings to the concepts of wellness and mindfulness, from dietary fads to fitness culture.
But Natural Causes goes deeper -- into the fundamental unreliability of our bodies and even our "mind-bodies," to use the fashionable term. Starting with the mysterious and seldom-acknowledged tendency of our own immune cells to promote deadly cancers, Ehrenreich looks into the cellular basis of aging, and shows how little control we actually have over it. We tend to believe we have agency over our bodies, our minds, and even over the manner of our deaths. But the latest science shows that the microscopic subunits of our bodies make their own "decisions," and not always in our favor.

We may buy expensive anti-aging products or cosmetic surgery, get preventive screenings and eat more kale, or throw ourselves into meditation and spirituality. But all these things offer only the illusion of control. How to live well, even joyously, while accepting our mortality -- that is the vitally important philosophical challenge of this book.

Drawing on varied sources, from personal experience and sociological trends to pop culture and current scientific literature, Natural Causes examines the ways in which we obsess over death, our bodies, and our health. Both funny and caustic, Ehrenreich then tackles the seemingly unsolvable problem of how we might better prepare ourselves for the end -- while still reveling in the lives that remain to us.

NEUROFITNESS

NEUROFITNESS

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From the operating room, where he performs some of the riskiest surgeries around, to the lab, where he works on leading clinical trials, Dr. Rahul Jandial is on the cutting edge of the latest advancements in neuroscience. This fascinating book draws on Dr. Jandial's broad-spectrum expertise and brings together the best of various fields--surgery, science, brain structure, the conscious mind--all to explain the bigger picture of brain health and rejuvenation. It is a journey into his operating room, around the world on his surgical missions, inside his laboratory, and to the outer edges of neuroscience to reveal the latest brain breakthroughs that are turning science fiction into reality, translating their implications for everyday life. Busting myths along the way, Jandial helps readers get wired for success at work and school, perform better when the pressure is on, boost memory, control stress and emotions, minimize pain, stick to a healthy eating plan, unleash creativity, raise smarter kids, and stay sharp as they age. Combining the treatment guidelines he gives his patients, the most promising concepts from frontier science, and the smartest super-achiever hacks, he provides practical takeaways for optimizing brain function and leading a healthier, happier, more productive life.
On Vanishing: Mortality, Dementia, and What It Means to Disappear

On Vanishing: Mortality, Dementia, and What It Means to Disappear

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An essential book for those coping with Alzheimer's and other cognitive disorders that "reframe[s] our understanding of dementia with sensitivity and accuracy . . . to grant better futures to our loved ones and ourselves" (Parul Sehgal, The New York Times).

An estimated fifty million people in the world suffer from dementia. Diseases such as Alzheimer's erase parts of one's memory but are also often said to erase the self. People don't simply die from such diseases; they are imagined, in the clichés of our era, as vanishing in plain sight, fading away, or enduring a long goodbye. In On Vanishing, Lynn Casteel Harper, a Baptist minister and nursing home chaplain, investigates the myths and metaphors surrounding dementia and aging, addressing not only the indignities caused by the condition but also by the rhetoric surrounding it. Harper asks essential questions about the nature of our outsized fear of dementia, the stigma this fear may create, and what it might mean for us all to try to "vanish well."

Weaving together personal stories with theology, history, philosophy, literature, and science, Harper confronts our elemental fears of disappearance and death, drawing on her own experiences with people with dementia both in the American healthcare system and within her own family. In the course of unpacking her own stories and encounters--of leading a prayer group on a dementia unit; of meeting individuals dismissed as "already gone" and finding them still possessed of complex, vital inner lives; of witnessing her grandfather's final years with Alzheimer's and discovering her own heightened genetic risk of succumbing to the disease--Harper engages in an exploration of dementia that is unlike anything written before on the subject.

A rich and startling work of nonfiction, On Vanishing reveals cognitive change as it truly is, an essential aspect of what it means to be mortal.

OUTBREAKS AND EPIDEMICS: BATTL

OUTBREAKS AND EPIDEMICS: BATTL

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For centuries mankind has waged war against the infections that, left untreated, would have the power to wipe out communities, or even entire populations. Yet for all our advanced scientific knowledge, only one human disease - smallpox - has ever been eradicated globally.

In recent years, outbreaks of Ebola and Zika have provided vivid examples of how difficult it is to contain an infection once it strikes, and the panic that a rapidly spreading epidemic can ignite.

But while we chase the diseases we are already aware of, new ones are constantly emerging, like the coronavirus that spread across the world in 2020. At the same time, antimicrobial resistance is harnessing infections that we once knew how to control, enabling them to thrive once more.

Meera Senthilingam presents a timely look at humanity's ongoing battle against infection, examining the successes and failures of the past, along with how we are confronting the challenges of today, and our chances of eradicating disease in the future.

SAWBONES BK

SAWBONES BK

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A compelling, often hilarious and occasionally horrifying exploration of how modern medicine came to be!

Wondering whether eating powdered mummies might be just the thing to cure your ills? Tempted by those vintage ads suggesting you wear radioactive underpants for virility? Ever considered drilling a hole in your head to deal with those pesky headaches? Probably not. But for thousands of years, people have done things like this--and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.

Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we're looking at you, raw water!) and be better able to figure out if this is a miracle cure (it's not) or a scam.

Table of Contents:

Part 1: The Unnerving
The Resurrection Men
Opium
An Electrifying Experience
Weight Loss
Charcoal
The Black Plague
Pliny the Elder
Erectile Dysfunction
Spontaneous Combustion
The Doctor Is In
Trepanation

Part II: The Gross
Mummy Medicine
Mercury
The Guthole Bromance
A Piece of Your Mind
The Unkillable Phineas Gage
Phrenology
The Man Who Drank Poop
Robert Liston
Urine Luck!
Radium
Humorism
The Doctor Is In
The Straight Poop

Part III: The Weird
The Dancing Plague
Curtis Howe Springer
Smoke 'Em if You Got ëEm
A Titanic Case of Nausea
Arsenic
Paracelsus
Honey
Self-Experimentation
Homeopathy
The Doctor Is In

Part IV: The Awesome
The Poison Squad
Bloodletting
Death by Chocolate
John Harvey Kellogg
Parrot Fever
Detox
Vinegar
Polio Vaccine
The Doctor Is In

SMOKE GETS IN YOUR EYES

SMOKE GETS IN YOUR EYES

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Armed with a degree in medieval history and a flair for the macabre, Caitlin Doughty took a job at a crematory and turned morbid curiosity into her life's work. She cared for bodies of every color, shape, and affliction, and became an intrepid explorer in the world of the dead. In this best-selling memoir, brimming with gallows humor and vivid characters, she marvels at the gruesome history of undertaking and relates her unique coming-of-age story with bold curiosity and mordant wit. By turns hilarious, dark, and uplifting, Smoke Gets in Your Eyes reveals how the fear of dying warps our society and "will make you reconsider how our culture treats the dead" (San Francisco Chronicle).

SPILLOVER: ANIMAL INFECTIONS A

SPILLOVER: ANIMAL INFECTIONS A

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The next big human pandemic--the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza--is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event "spillover" and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?

SPIRIT CATCHES YOU & YOU FALL

SPIRIT CATCHES YOU & YOU FALL

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When three-month-old Lia Lee arrived at the county hospital emergency room in Merced, California, a chain of events was set in motion from which neither she nor her parents, Foua and Nao Kao, were part of a large Hmong community in Merced, refugees from the CIA-run "Quiet War" in Laos. The Hmong, traditionally a close-knit and fiercely independent people, have been less amenable to assimilation than most immigrants, adhering steadfastly to the rituals and beliefs of their ancestors. Lia's pediatricians, Neil Ernst and his wife, Peggy Philip, cleaved just as strongly to another tradition: that of Western medicine. When Lia Lee entered the American medical system, diagnosed as an epileptic, her story became a tragic case history of cultural miscommunication.
STIFF

STIFF

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Stiff is an oddly compelling, often hilarious exploration of the strange lives of our bodies postmortem. For two thousand years, cadavers--some willingly, some unwittingly--have been involved in science's boldest strides and weirdest undertakings. In this fascinating account, Mary Roach visits the good deeds of cadavers over the centuries and tells the engrossing story of our bodies when we are no longer with them.
SUCCESSFUL AGING

SUCCESSFUL AGING

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INSTANT TOP 10 BESTSELLER *New York Times *USAToday *Washington Post *LA Times

"Debunks the idea that aging inevitably brings infirmity and unhappiness and instead offers a trove of practical, evidence-based guidance for living longer and better."
--Daniel H. Pink, author of When and Drive

SUCCESSFUL AGING delivers powerful insights:
- Debunking the myth that memory always declines with age
- Confirming that "health span"--not "life span"--is what matters
- Proving that sixty-plus years is a unique and newly recognized developmental stage
- Recommending that people look forward to joy, as reminiscing doesn't promote health

Levitin looks at the science behind what we all can learn from those who age joyously, as well as how to adapt our culture to take full advantage of older people's wisdom and experience. Throughout his exploration of what aging really means, using research from developmental neuroscience and the psychology of individual differences, Levitin reveals resilience strategies and practical, cognitive enhancing tricks everyone should do as they age.

Successful Aging inspires a powerful new approach to how readers think about our final decades, and it will revolutionize the way we plan for old age as individuals, family members, and citizens within a society where the average life expectancy continues to rise.

SURVIVAL OF THE SICKEST

SURVIVAL OF THE SICKEST

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Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.

So why does disease exist? Moalem proposes that most common ailments--diabetes, hemochromatosis, cystic fibrosis, sickle cell anemia--came into existence for very good reasons. At some point they helped our ancestors survive some grand challenge to their existence. Examining the evolution of man, Moalem reveals the role genetic and cultural differences have played in the health and well-being of various races, including their susceptibility to disease.

With mesmerizing insight, Moalem offers groundbreaking insight into:

- How diabetes may be a biproduct of a mechanism that helped humans survive the Ice Age

- Why African Americans living in the north might suffer from vitamin D deficiencies,

- Why Asians can't drink as much alcohol as Europeans

Revelatory, utterly engaging, and timely--Moalem ponders strongN1, the emerging Avian Flu virus--Why Redheads Feel More Pain and Asians Can't Drink will irrevocably change the way we think about our bodies and ourselves.

TALE OF THE DUELING NEUROSURGE

TALE OF THE DUELING NEUROSURGE

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The author of the bestseller The Disappearing Spoon reveals the secret inner workings of the brain through strange but true stories.

Early studies of the human brain used a simple method: wait for misfortune to strike -- strokes, seizures, infectious diseases, horrendous accidents -- and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. Parents suddenly couldn't recognize their own children. Pillars of the community became pathological liars. Some people couldn't speak but could still sing.

In The Tale of the Dueling Neurosurgeons, Sam Kean travels through time with stories of neurological curiosities: phantom limbs, Siamese twin brains, viruses that eat patients' memories, blind people who see through their tongues. He weaves these narratives together with prose that makes the pages fly by, to create a story of discovery that reaches back to the 1500s and the high-profile jousting accident that inspired this book's title.

With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways and recounts the forgotten tales of the ordinary people whose struggles, resilience, and deep humanity made neuroscience possible.

UNDYING: PAIN, VULNERABILITY,

UNDYING: PAIN, VULNERABILITY,

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WINNER OF THE 2020 PULITZER PRIZE IN GENERAL NONFICTION

The Undying is a startling, urgent intervention in our discourses about sickness and health, art and science, language and literature, and mortality and death. In dissecting what she terms 'the ideological regime of cancer, ' Anne Boyer has produced a profound and unforgettable document on the experience of life itself. --Sally Rooney, author of Normal People

Anne Boyer's radically unsentimental account of cancer and the 'carcinogenosphere' obliterates cliche. By demonstrating how her utterly specific experience is also irreducibly social, she opens up new spaces for thinking and feeling together. The Undying is an outraged, beautiful, and brilliant work of embodied critique. --Ben Lerner, author of The Topeka School

A week after her forty-first birthday, the acclaimed poet Anne Boyer was diagnosed with highly aggressive triple-negative breast cancer. For a single mother living paycheck to paycheck who had always been the caregiver rather than the one needing care, the catastrophic illness was both a crisis and an initiation into new ideas about mortality and the gendered politics of illness.

A twenty-first-century Illness as Metaphor, as well as a harrowing memoir of survival, The Undying explores the experience of illness as mediated by digital screens, weaving in ancient Roman dream diarists, cancer hoaxers and fetishists, cancer vloggers, corporate lies, John Donne, pro-pain "dolorists," the ecological costs of chemotherapy, and the many little murders of capitalism. It excoriates the pharmaceutical industry and the bland hypocrisies of "pink ribbon culture" while also diving into the long literary line of women writing about their own illnesses and ongoing deaths: Audre Lorde, Kathy Acker, Susan Sontag, and others.

A genre-bending memoir in the tradition of The Argonauts, The Undying will break your heart, make you angry enough to spit, and show you contemporary America as a thing both desperately ill and occasionally, perversely glorious.

Includes black-and-white illustrations

VOLUME CONTROL

VOLUME CONTROL

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The surprising science of hearing and the remarkable technologies that can help us hear better

Our sense of hearing makes it easy to connect with the world and the people around us. The human system for processing sound is a biological marvel, an intricate assembly of delicate membranes, bones, receptor cells, and neurons. Yet many people take their ears for granted, abusing them with loud restaurants, rock concerts, and Q-tips. And then, eventually, most of us start to go deaf.

Millions of Americans suffer from hearing loss. Faced with the cost and stigma of hearing aids, the natural human tendency is to do nothing and hope for the best, usually while pretending that nothing is wrong. In Volume Control, David Owen argues this inaction comes with a huge social cost. He demystifies the science of hearing while encouraging readers to get the treatment they need for hearing loss and protect the hearing they still have.

Hearing aids are rapidly improving and becoming more versatile. Inexpensive high-tech substitutes are increasingly available, making it possible for more of us to boost our weakening ears without bankrupting ourselves. Relatively soon, physicians may be able to reverse losses that have always been considered irreversible. Even the insistent buzz of tinnitus may soon yield to relatively simple treatments and techniques. With wit and clarity, Owen explores the incredible possibilities of technologically assisted hearing. And he proves that ears, whether they're working or not, are endlessly interesting.

WHY WE SLEEP

WHY WE SLEEP

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"Why We Sleep is an important and fascinating book...Walker taught me a lot about this basic activity that every person on Earth needs. I suspect his book will do the same for you." --Bill Gates

A New York Times bestseller and international sensation, this "stimulating and important book" (Financial Times) is a fascinating dive into the purpose and power of slumber.

With two appearances on CBS This Morning and Fresh Air's most popular interview of 2017, Matthew Walker has made abundantly clear that sleep is one of the most important but least understood aspects of our life. Until very recently, science had no answer to the question of why we sleep, or what good it served, or why we suffer such devastating health consequences when it is absent. Compared to the other basic drives in life--eating, drinking, and reproducing--the purpose of sleep remains more elusive.

Within the brain, sleep enriches a diversity of functions, including our ability to learn, memorize, and make logical decisions. It recalibrates our emotions, restocks our immune system, fine-tunes our metabolism, and regulates our appetite. Dreaming creates a virtual reality space in which the brain melds past and present knowledge, inspiring creativity.

In this "compelling and utterly convincing" (The Sunday Times) book, preeminent neuroscientist and sleep expert Matthew Walker provides a revolutionary exploration of sleep, examining how it affects every aspect of our physical and mental well-being. Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

Clear-eyed, fascinating, and accessible, Why We Sleep is a crucial and illuminating book. Written with the precision of Atul Gawande, Andrew Solomon, and Sherwin Nuland, it is "recommended for night-table reading in the most pragmatic sense" (The New York Times Book Review).

WILL MY CAT EAT MY EYEBALLS

WILL MY CAT EAT MY EYEBALLS

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Every day, funeral director Caitlin Doughty receives dozens of questions about death. The best questions come from kids. What would happen to an astronaut's body if it were pushed out of a space shuttle? Do people poop when they die? Can Grandma have a Viking funeral?

In Will My Cat Eat My Eyeballs?, Doughty blends her mortician's knowledge of the body and the intriguing history behind common misconceptions about corpses to offer factual, hilarious, and candid answers to thirty-five distinctive questions posed by her youngest fans. In her inimitable voice, Doughty details lore and science of what happens to, and inside, our bodies after we die. Why do corpses groan? What causes bodies to turn colors during decomposition? And why do hair and nails appear longer after death? Readers will learn the best soil for mummifying your body, whether you can preserve your best friend's skull as a keepsake, and what happens when you die on a plane.

Beautifully illustrated by Dianné Ruz, Will My Cat Eat My Eyeballs? shows us that death is science and art, and only by asking questions can we begin to embrace it.